Neem (Azadirachta indica) as a Biotechnological tool: a short review
DOI:
https://doi.org/10.33871/23594373.2019.21.02.2977Resumen
Neem (Azadirachta indica) is a plant native from India and very adaptable to hot climates. Commonly it has been found as an ornamental plant or used in popular medicine due to its herbal properties. The current work is a short review that aimed to discuss Neem' biotechnological application in agriculture, environment and pharmaceutical fields. The researches were performed using online databases and the papers that discussed the prospection of Neem in the agriculture field (as a fertilizer or playing plant protection against pests and disease), pharmaceutical industry (production of metabolites with biological activity) and environmental biotechnology (eco-friendly alternatives to mitigate chemical pesticide environ damage) have chosen. Based on Neem's properties is possible find it as a fertilizer, supplement for animal feed or playing important role in plant defenses against insects (bioinsecticide) and pathogenic microorganisms (antimicrobial activity) in the agriculture field or the pharmaceutical industry with metabolites which have antitumoral, antioxidant and anti-bactericidal activity, besides Neem has already been reported used in combination with nanoparticles. Overall, Neem has been mentioned as a great tool for biotechnological applications in different areas.
Descargas
Citas
CSURHES, S. Pest plant risk assessment neem tree Azadirachta indica. Plant Risk Assessment, v. 4001, p. 1-14, 2008.
EL-HAWARY, S.S; EL-TANTAWY, M.E.; RABEH, M.A; BADR, W.K. DNA fingerprinting and botanical study of Azadirachta indica A. Juss. (neem) family Meliaceae. Beni-Suef University Journal of Basic and Applied Sciences, v. 2, n. 1, p. 1-13, 2013.
FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS. FAOFAST. Disponível em:< http://www.fao.org/faostat/en/>. Acesso em: 27 Set. 2019.
GAJALAKSHMI, S.; ABBASI, S.A. Neem leaves as a source of fertilizer-cum-pesticide vermicompost. Bioresource Technology, v. 92, n. 3, p. 291-296, 2004.
GHAZANCHYAN, N.L.; KINOSYAN, M.H.; TADEVOSYAN, N.S.; KHACHATURYAN, N.S.; AFRIKIAN, E. G. Brevibacillus laterosporus as perspective source of new bioinsecticides. Annals of Agrarian Science, v. 16, n. 4, p. 413-415, 2018.
GUAN, A.; LIU, C.; YANG, X.; DEKEYSER, M. Application of the intermediate derivatization approach in agrochemical discovery. Chemical Reviews, v. 114, n. 14, p. 7079-7107, 2014.
GUPTA, S.C.; PRASAD, S.; TVAGI, A.K.; KUNNYMAKKARA, A.B.; AGGARWAL, B.B. Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis. Phytomedicine, v. 34, n. 15, p. 14-20, 2017.
HE, Z.; JIANG, C.; ZHANG, J.; YIN, Z.; YIN, Z.; ZHU, Y.; FU, J. Neem tree (Azadirachta indica) extract specifically suppresses the growth of tumors in H22-bearing Kunming mice. A Journal of Bioscience, v. 71, p. 7-8, 2016.
JINDAL, S. K.; VIR, S.; PANCHOLY, A. Variability and associations for seed yield, oil content and tree morphological traits in neem (Azadirachta indica). Journal of Tropical Forest Science, v. 11, n. 1, p. 320-322, 1999.
KALA, S.; NAIK, S.N.; PATANIALI, P.K.; SOGAN, N. Neem oil water dispersible tablet as effective larvicide, ovicide and oviposition deterrent agains Anopheles culicifacies. South African Journal of Botany, v. 123, p. 387-392, 2019.
KAMARULZAMAN, P.S.D.; YUSUP, S.; OSMAN, N.; RAMLI-YUSOF, N. H.; KUEH, B.W.B; TALIB, R. Effectiveness of neem based biopesticide to enhance rice (Oryza sativa) productivity. Sustainable Chemistry and Pharmacy, v. 7, p. 36-40, 2018.
KUMAR, R.; MEHTA, S.; PATHAK, S.R. Bioactive constituents of neem. In: TEWARI, A.; TEWARI, S. (Ed.). Synthesis of medicinal agents from plants. Copyright©. p, 75-103, 2018.
KUMAR, S.; SURESH, P.K.; VIJAYABABU, M.R.; ARUNKUMAR, A.; ARUNAKARAN, J. Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3). Journal of Ethnopharmacology, v. 105, n. 1-2, p. 246- 250, 2006.
KUMARI, P.; KUMAR, S.; RAMESH, M.; SHAMEENA, S.; DEO, A.D.; RAJENDRAN, K.V.; RAMAN, R.P. Antiparasitic effect of aqueous and organic solvent extracts of Azadirachta indica leaf against Argulus japonicus in Carassius auratus. Aquaculture, v. 511, 634175, 2019.
LOKANADHAN, S.; MUTHUKRISHNAN, P.; JEYARAMAN, S. Neem products and their agricultural applications. Journal of Biopesticides, v. 5, p. 72-76, 2012.
LQES-Laboratório de Química do Estado Sólido. 2001. O que é uma nanopartícula?. Disponível em:<http://lqes.iqm.unicamp.br/canal_cientifico/lqes_responde/lqes_responde_nanoparticula.html> Acesso em: Agosto de 2019.
MAK-MENSAH, E.E.; FIREMPONG, C. K. Chemical characteristics of toilet soap prepared from neem (Azadirachta indica A. juss) seed oil. Asian Journal of Plant Science and Research, v. 1, n. 4, p. 1-7, 2011.
MATTOS, B.D.; ROJAS, O.J.; MAGALHAES, W.L.E. Biogenic silica nanoparticles loaded with neem bark extract as green, slow-release biocide. Journal of Cleaner Production, v. 142, n. 4, p. 4206-4213, 2017.
MONDAL, D.; MONDAL, T. A review on efficacy of Azadirachta indica A. Juss based biopesticides: an Indian perspective. Research Journal of Recent Sciences, v. 1, p. 94-99, 2012.
MULLA, M.S.; SU, T. Activity and biological effects of neem products against arthropods of medicinal and veterinary importance. Journal of American Mosquitos Control Association, v. 15, p. 133-152, 1999.
MUSALIA, L.M. ANANDAN, S.; SASTRY, V.R.B.; AGRAWAL, D.K. Urea-treated neem (Azadirachta indica A. Juss) seed kernel cake as a protein supplement for lambs. Small Ruminant Research, v. 35, n. 2m p. 107-116, 2000.
NDIONE, R.D.; FAYE, O.; NDIAYE, M.; DIEYE, A.; AFOUTOU, J.M. Toxic effects of neem products (Azadirachta indica A. Juss) on Aedes aegypti Linnaeus 1763 larvae. African Journal of Biotechnology, v. 6, p. 2846-2854, 2007.
NICOLETTI, M.; MACCIONI, O.; COCCIOLETTI, T.; MARIANI, S.; VITALI, F. Neem Tree (Azadirachta indica A. Juss) as source of bioinsectides. In: PERVEEN, F (Ed.). Insecticides Advances in Integrated Pest Management. In Tech, p. 411-426, 2012.
OKUMU, F.O.; KNOLS, B.G.; FILLINGER, U. Larvicidal effects of a neem (Azadirachta indica) oil formulation on the malaria vector Anopheles gambiae. Malaria Journal, v. 6, p. 63-67, 2007.
PASCOLI, M.; JACQUES, M.T.; AGARRAYUA, D.A.; AVILA, D.S.; LIMA, R.; FRACETO, L.F. Neem oil based nanopesticide as an environmentally-friendly formulation for applications in sustainable agriculture: an ecotoxicological perspective. Science of the total environment, v. 677, p. 57-67, 2019.
PASSOS, M.S.; CARVALHO-JUNIOR, A.R.; BOENOA, S.I; VIRGENS, L.L.G.; CALIXTOC, S.D.; VENTURAC, T.L.B.; LASSOUNSKAIAC, E.; FILHOA, R.B.; VIEIRA, I.J.C. Terpenoids isolated from Azadirachta indica roots and biological activities. Revista Brasileira de Farmacognosia, v. 29, n. 1, p. 40-45, 2019.
PUNT, L. Neem based insecticides. Homes & Gardens News. 2000.
SANTOS, L.U.; ANDRADE, C.F.S. Azadirachta indica- A árvore do Nim e o controle de piolhos. Departamento de Zoologia, IB: UNICAMP, 2000.
SIDDIQ, A.M.; MADHAN, B.; RAMAR, T.; ALAM, M.S. Green (gemini) surfactant mediated gold nanoparticles green synthesis: Effect on triple negative breast cancer cells. Nano-Structures & Nano-Objects, v. 19, 100373, 2019.
SU, T.; MULLA, A. S. Oviposition bioassay responses of Culex tarsalis and Culex quinquefasciatus to neem products containing azadirachtin. Entomologia Experimentalis et Applicata, v. 91, p. 337-345, 1999.
SUBRAMANI, K.; MURUGAN, V.; SHANMUGAM, B.K.; RANGARAJ, S.; PALANISAMY, M.; VENKATACHALAM, R.; SURESH, V. An ecofriendly route to enhance the antibacterial and textural properties of cotton fabrics using herbal nanoparticles from Azadirachta indica (neem). Journal of Alloys and Compounds, v. 723, p. 698-707, 2017.
SCOPUS. Analyze search results. Disponível em:< https://www.scopus.com>. Acesso em 27 Setembro. 2019.
TRIPATHY, A.; RAICHUR, A.M.; CHANDRASEKARAN, N.; PRATHNA, T.C.; MUKHERJEE, A. Process variables in biomimetic synthesis of silver nanoparticles by aqueous extract of Azadirachta indica (neem) leaves. Journal of Nanoparticle Research, v. 12, n. 1, p. 237-246, 2010.
VERMA, A.; MEHATA, M.S. Controllable synthesis of silver nanoparticles using Neem leaves and their antimicrobial activity. Journal of Radiation Research and Applied Sciences, v. 9, n. 1, p. 109-115, 2016.
VIJAYAN, V. Formulation and characterization of solid lipid nanoparticles loaded Neem oil for topical treatment of acne. Journal of Acute Disease, v. 2, n. 4, p. 282-286, 2013.
Descargas
Publicado
Número
Sección
Licencia
Todas as informações, opiniões, dados, referências, citações e posicionamentos
expressos nos textos científicos publicados são de inteira responsabilidade dos seus respectivos autores/escritores, cabendo-lhes os elogios, as críticas e as possíveis conseqüências legais e jurídicas.Uma vez aceito para publicação, o autor concorda em ceder os direitos autorais da publicação do texto científico encaminhado à revista Luminária.
